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The four-quadrant amniotic fluid index tended to increase in both groups, with an overall nonsignificant increase of 32% ± 16% 1 hour after the infusions. These urine flow changes correlated with opposite changes in fetal plasma osmolality. Fetal urine flow decreased at the end of the Ringer's infusion and increased during the hypotonic infusion. Fetal heart rate decreased by 15 to 20 beats/min by 1.5 hours of infusion in both groups but remained decreased only in the hypotonic group. Fetal vascular pressures and blood volume were unchanged during either infusion. The maternal osmolality changes during the Ringer's infusion (−5.7 ± 1.2 mOsm/kg at 1 hour and +6.8 ± 1.1 mOsm/kg at 5 hours) were significantly less ( p < 0.00001) than those during the hypotonic infusion (−10.2 ± 1.1 mOsm/kg at 1 hour and −15.9 ± 2.5 mOsm/kg at 5 hours). During the Ringer's solution infusion, the increases in maternal arterial (20.7 ± 1.7 mm Hg, mean ± SE) and venous (6.6 ± 0.9 mm Hg) pressures were significantly greater ( p<0.00001) than those during the hypotonic infusion (6.6 ± 1.5 and 1.7 ± 0.6 mm Hg, respectively).
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